The real world and thinking of thyroid cancer in China

Lin Han, Zhen Wu, Wen-lei Li, Yingxue Li, Jin-Quan Ma, Xinxin Wu, Wenjuan Wen, Rui Li, Yu-min Yao, Yongkun Wang
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引用次数: 4

Abstract

Summary: The incidence of thyroid cancer has increased year by year, which has a major impact on the physical and mental health of patients. At the same time, it has a heavy psychological and economic burden on society and individuals. Based on the actual data of the thyroid cancer in Liaocheng People’ Hospital in 2017, combine with the national and regional characteristics of China, this paper analyzes and discusses the controversy of initial thyroid operation modus. Materials and methods: The clinical and pathologic data of 552 patients of thyroid cancer were collected from the department of thyroid surgery, who were initially discovered and treated surgically. 40 patients underwent endoscopic surgery, the range of resection was lobectomy+central lymph node dissection of the affected lobe. There were 512 cases underwent open operation with total thyroidectomy+central lymph node dissection, 239 of which were treated with neck lateral lymph node dissection at the same time. Results: The overall metastasis rate of all patients was 59.42%. Even the lymph node metastasis of papillary thyroid microcarcinoma was as high as 46.92%. When the mass rose above 2 cm, the proportion of metastasis increased to 77.53%. When the tumor was complicated with bilateral and multiple high risk factor etc the proportion of metastasis were 63.54% and 71.19%, respectively. Meanwhile, the incidence of contralateral accidental malignancy was 7.25% after postoperative paraffin pathology. Conclusion: The malignant degree of thyroid cancer depends on the evolution of the tumor genome and there is a high rate of neck lymph node metastasis, especially when associated with high risk factors. It is recommended that at least total thyroidectomy+central lymph node dissection should be performed in initial treatment in China to avoid the risk of secondary operation and the burden of body and mind.
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中国甲状腺癌的现实世界与思考
摘要:甲状腺癌的发病率逐年上升,对患者的身心健康产生重大影响。与此同时,它给社会和个人带来了沉重的心理和经济负担。本文根据聊城市人民医院2017年甲状腺癌的实际数据,结合中国的国家和地区特点,对甲状腺初始手术方式的争议进行了分析和探讨。材料与方法:收集甲状腺外科552例甲状腺癌患者的临床和病理资料,这些患者最初都是通过手术发现和治疗的。40例患者行内镜手术,切除范围为肺叶切除+患叶中央淋巴结清扫。开腹手术加甲状腺全切除术+中央淋巴结清扫512例,其中239例同时行颈部外侧淋巴结清扫。结果:所有患者的总转移率为59.42%。甲状腺乳头状微癌的淋巴结转移率也高达46.92%。当肿块增大到2 cm以上时,转移比例增加到77.53%。当肿瘤合并双侧及多重高危因素等时,发生转移的比例分别为63.54%和71.19%。术后石蜡病理检查对侧意外恶性肿瘤发生率为7.25%。结论:甲状腺癌的恶性程度取决于肿瘤基因组的进化,颈部淋巴结转移率高,尤其是与高危因素相关时。国内建议初始治疗至少行甲状腺全切除术+中央淋巴结清扫,避免二次手术风险和身心负担。
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