H-J Gabius, J C Manning, J Kopitz, S André, H Kaltner
{"title":"Sweet complementarity: the functional pairing of glycans with lectins.","authors":"H-J Gabius, J C Manning, J Kopitz, S André, H Kaltner","doi":"10.1007/s00018-016-2163-8","DOIUrl":null,"url":null,"abstract":"<p><p>Carbohydrates establish the third alphabet of life. As part of cellular glycoconjugates, the glycans generate a multitude of signals in a minimum of space. The presence of distinct glycotopes and the glycome diversity are mapped by sugar receptors (antibodies and lectins). Endogenous (tissue) lectins can read the sugar-encoded information and translate it into functional aspects of cell sociology. Illustrated by instructive examples, each glycan has its own ligand properties. Lectins with different folds can converge to target the same epitope, while intrafamily diversification enables functional cooperation and antagonism. The emerging evidence for the concept of a network calls for a detailed fingerprinting. Due to the high degree of plasticity and dynamics of the display of genes for lectins the validity of extrapolations between different organisms of the phylogenetic tree yet is inevitably limited. </p>","PeriodicalId":53999,"journal":{"name":"Aestimum","volume":"1 1","pages":"1989-2016"},"PeriodicalIF":0.8000,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11108359/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aestimum","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00018-016-2163-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/3/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ECONOMICS","Score":null,"Total":0}
引用次数: 0
Abstract
Carbohydrates establish the third alphabet of life. As part of cellular glycoconjugates, the glycans generate a multitude of signals in a minimum of space. The presence of distinct glycotopes and the glycome diversity are mapped by sugar receptors (antibodies and lectins). Endogenous (tissue) lectins can read the sugar-encoded information and translate it into functional aspects of cell sociology. Illustrated by instructive examples, each glycan has its own ligand properties. Lectins with different folds can converge to target the same epitope, while intrafamily diversification enables functional cooperation and antagonism. The emerging evidence for the concept of a network calls for a detailed fingerprinting. Due to the high degree of plasticity and dynamics of the display of genes for lectins the validity of extrapolations between different organisms of the phylogenetic tree yet is inevitably limited.
期刊介绍：
Aestimum is a peer-reviewed Journal dedicated to the methodological study of appraisal and land economics. Established in 1976 by the Italian Association of Appraisers and Land Economists, which was legally recognized by Ministerial Decree, March 1993. Topics of interests comprise rural, urban and environmental appraisal, evaluation of public investments and land use planning. All the areas under discussion are addressed to the International scene. The interdisciplinary approach is one of the mainstays of this editorial project and all of the above mentioned topics are developed taking into consideration the economic, legal and urban planning aspects. Aestimum is biannual Journal and publishes articles both in Italian and English. Articles submitted are subjected to a double blind peer review process.
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