A Study of clinical and biochemical profile of Metabolic Syndrome in Acute myocardial Infarction

Abstract

The term “Metabolic Syndrome” has become widely used since its inception in 2001 by the NCEPATPIII, the concept of “clustering” metabolic disorders and Cardiovascular Disease (CVD) risk factors has been discussed in the scientific literature for many decades. The highest recorded prevalence worldwide is in Native Americans, with nearly 60% of women ages 45–49 and 45% of men ages 45–49 meeting NCEP:ATPIII criteria. Prevalence of the metabolic syndrome ranges from about 11 to 41 per cent in different regions of India. The present study is a one year cross sectional study that aims to study the prevalence of metabolic syndrome in patients with acute myocardial infarction and to assess and analyse the prevalence of individual components of metabolic syndrome in patients with acute myocardial infarction & also its impact on the prognosis of patients with acute myocardial infarction during one week of in-hospital stay, admitted to Rajendra Institute of Medical Sciences , Ranchi. Data was collected during their hospital stay & descriptive statistical analysis ,.Test of proportion, Chi-square ( 2  ) Odds Ratio (OR) with 95% confidence limit were used for statistical analysis. The prevalence of metabolic syndrome in acute MI in our study (49.2 %). .The body mass index (BMI) of> 25 kg/m 2 was found to be present in 84.6 % of patients with metabolic syndrome. Serum Triglycerides was found to be higher in our study compared to other studies. The mean values of HDL-C and Waist Circumference (WC) were found to be lower in our study compared to other studies. .Among the components of metabolic syndrome, low HDL-C was the most prevalent component among Metabolic syndrome patients .Development of complications (heart failure, arrythmias, re-infarction and case mortality) was significantly higher in patients of metabolic syndrome compared to those without metabolic syndrome. Case mortality among patients of acute MI with metabolic syndrome was found to be 27.7 %.