Decade Research Progress and Development Trend of Complex Prescription Compatibility of Traditional Chinese Medicine

World Science and Technology Pub Date : 2012-06-01 DOI:10.1016/S1876-3553(13)60003-4

Ge Yingli , Lu Yanliu , Yang Ming , Song Haiyan , Liu Ping , Ji Guang

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引用次数: 3

Abstract

Complex prescription is the primary therapeutic method of traditional Chinese medicine (TCM). It is a key influencing factor in prescription compatibility. During the past decade, researchers have carried out explorations on the compound compatibility law through aspects of pharmacodynamics (PD), pharmacokinetics (PK) and the combination of PD and PK (PD-PK) and achieved significant success. However, a TCM prescription contains various components. The functions of components and the complex interactions among the different components and their metabolic changes in the body have not been well understood. By far, reasonable and standard methods are still lacking in the study of component compatibility of TCM complex prescription. Based on a summary of recent studies of complex prescription, we put forward the new research method of complex prescription compatibility through multi-index comprehensive evaluation for PD-PK indexes of the efficacious components compatibility law.

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中药复方配伍十年研究进展及发展趋势

复方方剂是中医的主要治疗方法。它是影响处方配伍的关键因素。近十年来，研究人员从药效学(PD)、药代动力学(PK)以及PD-PK联用(PD-PK)等方面对复方配伍规律进行了探索，取得了显著的成功。然而，中药处方包含多种成分。各组分的功能、各组分之间复杂的相互作用及其在体内的代谢变化尚未得到很好的了解。到目前为止，中药复方组份配伍研究还缺乏合理规范的方法。在总结近年来复方配伍研究的基础上，通过对有效成分配伍规律的PD-PK指标进行多指标综合评价，提出了复方配伍研究的新方法。

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World Science and Technology

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