{"title":"A Review On The Role Of Nitric Oxide In The Pathophysiology And Management Of Sars- Cov-2 Disease","authors":"S. Chadha, Sayali Mukherjee, Somali Sanyal","doi":"10.2174/2666796704666230608120444","DOIUrl":null,"url":null,"abstract":"\n\nSARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe form.\n","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronaviruses","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2666796704666230608120444","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
SARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe form.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
