Cai Hong-pei, D. Zhihua, Li Shi, Zhang Xingrong, Shen Jianwei
{"title":"Inhibitory effect of arsenic trioxide on peritoneal metastasis in nude mice with colon cancer","authors":"Cai Hong-pei, D. Zhihua, Li Shi, Zhang Xingrong, Shen Jianwei","doi":"10.1046/J.1443-9573.2000.00007.X","DOIUrl":null,"url":null,"abstract":"OBJECTIVE: To investigate the effects of As2O3 on the peritoneal metastasis of colon cancer in nude mice. \n \n \n \nMETHODS: BALB/c-nu/nu mice were injected intraperitoneally with Lovo cells and were allocated to five groups at random: control, epirubicin and varying concentrations of As2O3. The length of their survival period and rates of tumorigenesis and ascitic fluid formation were evaluated. \n \n \n \nRESULTS: Epirubicin and low doses of As2O3 clearly inhibited ascitic fluid formation and extended the survival period of tumor-bearing nude mice. Moderate and large doses of As2O3 were able to eradicate cancer cells through apoptosis. \n \n \n \nCONCLUSIONS: As2O3 can induce apoptosis in intraperitoneal colon cancer cells, inhibit ascitic fluid formation and extend the survival periods of nude mice to varying degrees.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese journal of digestive diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1046/J.1443-9573.2000.00007.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
OBJECTIVE: To investigate the effects of As2O3 on the peritoneal metastasis of colon cancer in nude mice.
METHODS: BALB/c-nu/nu mice were injected intraperitoneally with Lovo cells and were allocated to five groups at random: control, epirubicin and varying concentrations of As2O3. The length of their survival period and rates of tumorigenesis and ascitic fluid formation were evaluated.
RESULTS: Epirubicin and low doses of As2O3 clearly inhibited ascitic fluid formation and extended the survival period of tumor-bearing nude mice. Moderate and large doses of As2O3 were able to eradicate cancer cells through apoptosis.
CONCLUSIONS: As2O3 can induce apoptosis in intraperitoneal colon cancer cells, inhibit ascitic fluid formation and extend the survival periods of nude mice to varying degrees.
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