DEVELOPMENT OF A METHOD FOR DETERMINATION OF M-CRESOL IN A DRUG OF DISSOLVED INJECTION INSULIN

M. Jalilov, Zulaykho Sumanova, Nigora Kutlimuratona
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Abstract

This article presents the results of the development of a methodic for the determination of metacresol in a medicinal product of dissolved injectable insulin. The choice of the reagent for the complexation reaction, finding the λ maximum of the complex of the reagent (FeCl3) with m-cresol, the effect of pH on the analytical signal was studied. The straightness of the optical density in the determination of m-cresol in the concentration range of 0.625–12.5 mg / 8 ml with a correlation coefficient (R2) of 0.981 at λ max 567 nm has been proved. Ключевые слова: м-крезол, инсулин,
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溶性胰岛素注射液中间甲酚含量测定方法的建立
本文介绍了溶性注射胰岛素制剂中甲克雷醇含量测定方法的发展结果。络合反应试剂的选择,确定了FeCl3与间甲酚络合物的λ最大值,研究了pH对分析信号的影响。在0.625 ~ 12.5 mg / 8 ml浓度范围内测定间甲酚的光密度具有直线性,在λ max 567 nm处相关系数(R2)为0.981。Ключевые слова: -крезол, инсулин,
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