Nicotinic and non-nicotinic receptor-mediated mechanisms responsible for anti-atrophy effects in muscle

Y. Kakinuma
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Abstract

Recently, cholinergic modulation of immune cells has drawn particular interests from researchers in clinical fields, which may lead to a breakthrough that produces a novel therapeutic modality. Other than the immunological aspects, cholinergic modulation may also provide clues for accelerating angiogenesis and preventing any associated muscle atrophy. In this Research highlight, we discuss our recent findings in the context of research advancements, focusing on nicotinic and non-nicotinic receptor-mediated anti-muscular atrophy effects.
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烟碱和非烟碱受体介导的肌肉抗萎缩作用机制
近年来,免疫细胞的胆碱能调节引起了临床研究人员的特别关注,这可能会导致一种新的治疗方式的突破。除了免疫方面,胆碱能调节也可能为加速血管生成和预防任何相关的肌肉萎缩提供线索。在本研究重点中,我们讨论了我们在研究进展背景下的最新发现,重点关注烟碱和非烟碱受体介导的抗肌萎缩作用。
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