Therapeutic approaches and challenges for modulating the microbiota to prevent adenoma colon cancer

2区 医学 Q1 Medicine Advances in Cancer Research Pub Date : 2023-01-01 DOI:10.53388/2023623016
A. Patil, Neha Singh, Nita Pawar
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引用次数: 0

Abstract

New research suggests that gut microbiota helps adenoma colon cancer spread worldwide. This study seeks therapeutic microbiota changes to prevent adenoma colon cancer and discusses their drawbacks. Prebiotics feed good bacteria and promote the formation of short-chain fatty acids, which have anti-inflammatory and anti-cancer properties. To promote healthy gut bacteria and reduce adenoma risk, fiber-rich diets and particular dietary interventions are being researched. FMT (fecal microbiota transplantation) may help restore gut flora and prevent adenoma colon cancer, according to the study. FMT transfers healthy donor feces to patients to restore microbial diversity. Different gut flora, persons, and therapies make it tricky to draw conclusions. Personalizing therapeutic approaches to each person’s microbiota, host features, and genetic factors can improve treatment. Changing microorganisms may prevent adenoma colon cancer. Probiotics, prebiotics, dietary modifications, FMT, and bacteria metabolites may assist. More research is needed to determine the best ways to aid, solve difficulties, and personalize methods. We can prevent adenoma colon cancer and improve public health by learning more about gut flora and optimizing treatment methods.
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调节微生物群预防腺瘤结肠癌的治疗方法和挑战
新的研究表明,肠道微生物群有助于结肠癌腺瘤在全球范围内扩散。本研究寻求治疗性微生物群改变以预防腺瘤结肠癌,并讨论其缺点。益生元喂养有益细菌,促进短链脂肪酸的形成,短链脂肪酸具有抗炎和抗癌的特性。为了促进健康的肠道细菌和降低腺瘤风险,人们正在研究富含纤维的饮食和特定的饮食干预措施。根据这项研究,FMT(粪便微生物群移植)可能有助于恢复肠道菌群和预防腺瘤结肠癌。FMT将健康的供体粪便转移给患者,以恢复微生物多样性。不同的肠道菌群,不同的人,不同的治疗方法使得得出结论很困难。针对每个人的微生物群、宿主特征和遗传因素的个性化治疗方法可以改善治疗。改变微生物可能预防腺瘤结肠癌。益生菌、益生元、饮食调整、FMT和细菌代谢物可能有帮助。需要更多的研究来确定帮助、解决困难和个性化方法的最佳方法。我们可以通过更多地了解肠道菌群和优化治疗方法来预防腺瘤结肠癌,改善公众健康。
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来源期刊
Advances in Cancer Research
Advances in Cancer Research 医学-肿瘤学
CiteScore
10.00
自引率
0.00%
发文量
52
期刊介绍: Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. The first ACR volume came out in the year that Watson and Crick reported on the central dogma of biology, the DNA double helix. In the first 100 volumes are found many contributions by some of those who helped shape the revolution and who made many of the remarkable discoveries in cancer research that have developed from it.
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