Neuro-protective effect of Linalool against spinal cord injury in rats and the mechanism involved

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI:10.37360/blacpma.23.22.2.16

Lei Zhang, Wendong Sun, Lianjin Li, Xiangqian Zhang, J. Tong

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Abstract

The current study was conducted to determine the neuroprotective role and mechanism of action of Linalool (LIN) in SCI. The SCI in Sprague-Dawley (SD) rats was induced by weight-drop contusion model. Results of the suggested that LIN showed improvement in the locomotor function of SCI rats in a BBB scoring analysis. It was found in agreement with histopathological analysis of spinal cord tissue where LIN improves the neuronal architecture of spinal cord tissues, and protect neurons from degeneration. It also reduces oxidative stress via modulating endogenous antioxidants (MDA, SOD, and GSH) and inhibits the generation of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). In western blot analysis, LIN showed dose-dependent reduction of expression of toll-like receptor (TLR-4) and nuclear factor-kappa B (NF-ĸB). Our study demonstrated that administration of Linalool alleviated spinal cord injury via anti-inflammatory and antioxidant activities in spinal cord tissues possibly due to inhibition of TLR4/NF-κB activation.

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芳樟醇对大鼠脊髓损伤的神经保护作用及其机制

本研究旨在探讨芳樟醇(Linalool, LIN)在脊髓损伤中的神经保护作用及其机制。采用失重挫伤模型对SD大鼠进行脊髓损伤模型研究。结果表明，在BBB评分分析中，LIN可以改善脊髓损伤大鼠的运动功能。这与脊髓组织的组织病理学分析一致，其中LIN改善脊髓组织的神经元结构，并保护神经元免受退化。它还通过调节内源性抗氧化剂(MDA、SOD和GSH)和抑制促炎细胞因子(TNF-α、IL-1β和IL-6)的产生来减少氧化应激。western blot分析显示，LIN显示toll样受体(TLR-4)和核因子κ B (NF-ĸB)的表达呈剂量依赖性降低。我们的研究表明，芳樟醇通过脊髓组织的抗炎和抗氧化活性减轻脊髓损伤，可能是由于抑制TLR4/NF-κB的激活。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.