{"title":"Efficacy of therapeutic nanoformulations in a collagen-based three-dimensional colorectal cancer in vitro model","authors":"Victor Lopez Davila","doi":"10.4172/2157-7552.S1.022","DOIUrl":null,"url":null,"abstract":"Methods: AZD6244-containing GCPQ micelles and DOPE/DC-cholesterol liposomes were fabricated using sonication and extrusion methods respectively. These formulations were tested together with the free drug in HCT116 cell monolayers and a collagen-based 3D cancer model to determine differences in efficacy between both models. Fluorescent nanoparticles were used to determine their ability to penetrate the scaffold and reach its core.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":"73 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2015-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Tissue Science and Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2157-7552.S1.022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Methods: AZD6244-containing GCPQ micelles and DOPE/DC-cholesterol liposomes were fabricated using sonication and extrusion methods respectively. These formulations were tested together with the free drug in HCT116 cell monolayers and a collagen-based 3D cancer model to determine differences in efficacy between both models. Fluorescent nanoparticles were used to determine their ability to penetrate the scaffold and reach its core.
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