Neonatal Sepsis and Associated Factors Among Neonates Admitted to Neonatal Intensive Care Unit in General Hospitals, Eastern Ethiopia 2020

IF 1.7 Q2 PEDIATRICS Clinical Medicine Insights-Pediatrics Pub Date : 2022-01-01 DOI:10.1177/11795565221098346
Abdurahman Kedir Roble, Liyew Mekonen Ayehubizu, Hafsa Mohamed Olad
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引用次数: 6

Abstract

Introduction: Globally, the major cause of neonatal mortality and morbidity is neonatal sepsis, which is defined as a clinical course marked by systemic inflammation in the presence of infection in a newborn. There are limited data concerning neonatal sepsis in eastern Ethiopia. As a result, this study aimed to determine the prevalence of neonatal sepsis and associated factors among neonates admitted to intensive care units at general hospitals in Eastern Ethiopia. Methods: A hospital-based cross-sectional study with retrospective document review was conducted among newborns hospitalized in neonatal intensive care units. Using simple random sampling, the charts of 356 newborns who were hospitalized between January and December 2019 were included, and data were collected using a pretested checklist. Data were entered into Epi data version 3.1 and analyzed with SPSS version 22. Results: The overall prevalence of neonatal sepsis was 45.8% (95% CI 40.7, 51.4). Prolonged rupture of the membrane (AOR = 2.38, 95% CI: [1.27-4.45]), vaginal delivery (AOR = 1.78, 95%, CI: [1.09, 2.96]) APGAR score <7 (AOR = 4.55, 95% CI: [2.49-8.29]), prelacteal feeding (AOR = 3.54, 95% CI: [1.68-8.23]), and mechanical ventilation (AOR = 4.97,95%CI: [2.78-8.89]) were predictors associated with neonatal sepsis. Conclusion: In this study, the prevalence of neonatal sepsis was high, and factors associated with neonatal sepsis included prolonged rupture of membrane, mode of delivery, low APGAR score, prelacteal feeding and mechanical ventilation. As a result, maternal and neonatal care should be enhanced to lower the risk of neonatal sepsis.
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埃塞俄比亚东部综合医院新生儿重症监护室新生儿脓毒症及其相关因素
在全球范围内,新生儿死亡和发病的主要原因是新生儿败血症,它被定义为新生儿感染时全身性炎症的临床过程。关于埃塞俄比亚东部新生儿败血症的数据有限。因此,本研究旨在确定埃塞俄比亚东部综合医院重症监护病房收治的新生儿中新生儿败血症的患病率及其相关因素。方法:对在新生儿重症监护病房住院的新生儿进行以医院为基础的横断面研究和回顾性文献复习。通过简单的随机抽样,纳入了2019年1月至12月期间住院的356名新生儿的图表,并使用预测试的清单收集数据。数据录入Epi数据3.1版,使用SPSS 22版进行分析。结果:新生儿脓毒症的总患病率为45.8% (95% CI 40.7, 51.4)。胎膜破裂时间延长(AOR = 2.38, 95%CI:[1.27 ~ 4.45])、阴道分娩(AOR = 1.78, 95%CI:[1.09 ~ 2.96])、APGAR评分<7 (AOR = 4.55, 95%CI:[2.49 ~ 8.29])、乳前喂养(AOR = 3.54, 95%CI:[1.68 ~ 8.23])、机械通气(AOR = 4.97,95%CI:[2.78 ~ 8.89])是新生儿脓毒症的预测因素。结论:本研究中新生儿脓毒症患病率较高,与新生儿脓毒症相关的因素包括胎膜破裂时间延长、分娩方式、低APGAR评分、乳前喂养、机械通气等。因此,应加强孕产妇和新生儿护理,以降低新生儿败血症的风险。
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8 weeks
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