Optimal Control Techniques for the Role of Antiretroviral Therapy (ART) Abuse in HIV/AIDS Treatment Dynamics

Abstract

: From the studies of HIV/AIDS transmission and treatment dynamics using mathematical modeling, literature reviews have shown that attention had not been given to the behavioral attitude of screen-aware infectives not ready to receive treatment, HIV-aware infectives that initiated treatment but truncated only to resume treatment later (therapy abuse) and those on consistent treatment protocols. Moreso, following the non-outright eradication of the deadly HI-virus, recommendations have been geared towards exploring optimal control theory for the maximization of healthy uninfected CD4 + T-cells. Therefore, this present investigation seeks and formulated an optimal control 6-Dimensional deterministic mathematical dynamic model, which accounted for the Role of Antiretroviral Therapy (ART) abuse in the treatment dynamics of the HIV/AIDS epidemic. The materials and methods for this model are constituted by a set of 6-Dimensional varying subpopulations interacting with concentrated HI-viral load. Interactions are investigated using bilinear control functions (condom use and ART) with empirically generated data. The model assumed a deterministic approach and was formulated using the fundamental theory of differential equations. Theoretical optimal predictions explored classical numerical methods with optimal control techniques (Pontryagin's maximum principle in conjunction with Hessian matrix) as a basis. Numerical simulations were conducted using in-built Runge-Kutta of the order of precision 4 in a Mathcad surface. Following the derived model for both off-optimal control and onset-optimal control functions and model optimal control pair as well as model optimality system, results of simulations indicated that at off-optimal control function, near zero population extinction was observed. From the application of optimal control functions under optimal control techniques, there exists tremendous rejuvenation of susceptible populations vindicated by a reduction in the rate of ART abuse under a minimal proportion of bilinear control functions. The study concluded that adopting optimal control techniques for the investigation of the role of ART abuse in HIV/AIDS treatment yield highly significant recovery of healthy CD4 + T-Cells at minimal systemic cost when compared with off-optimal control outcome. Therefore, the study not only affirmed the vital concept of optimal control strategy but also, instituted the viability of the model. Thus, this model can be extensively used in Bio-system and applied mathematics.