{"title":"Herd Immunity Conferred By Hepatitis B Vaccination Increases the Protection Efficacy against Hepatitis B Virus Infection","authors":"Yuting Wang, Ling-ling Lu, Dongmei Wang, C. Qu","doi":"10.17140/vroj-1-103","DOIUrl":null,"url":null,"abstract":"Most of the chronic infections with Hepatitis B Virus (HBV) are acquired in perinatal period or in early life in China. We conducted HBV serosurveys in the same community among the age 5-6 year old children who were born in 1979-1980, in 1985-1986, and in 2002-2003, respectively. The seropositive rate of HBV surface antigen (HBsAg) was 11.43% in the unvaccinated population. It decreased to 2.08% among the vaccinated children born in the same year. With increased vaccination coverage the HBsAg seropositive rate decreased to 0.24% among the age 6-7 year old children born in 2002-2003, with 98.21% protection efficacy. Herd immunity conferred by HBV vaccination increases the protection efficacy against HBV infection.","PeriodicalId":93237,"journal":{"name":"Vaccination research : open journal","volume":"17 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vaccination research : open journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17140/vroj-1-103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Most of the chronic infections with Hepatitis B Virus (HBV) are acquired in perinatal period or in early life in China. We conducted HBV serosurveys in the same community among the age 5-6 year old children who were born in 1979-1980, in 1985-1986, and in 2002-2003, respectively. The seropositive rate of HBV surface antigen (HBsAg) was 11.43% in the unvaccinated population. It decreased to 2.08% among the vaccinated children born in the same year. With increased vaccination coverage the HBsAg seropositive rate decreased to 0.24% among the age 6-7 year old children born in 2002-2003, with 98.21% protection efficacy. Herd immunity conferred by HBV vaccination increases the protection efficacy against HBV infection.
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