Comparative Study and Analysis of Clotting Profiles Between Covid-19 And NonCovid-19 Patients In Barau Dikko Teaching Hospital, Kaduna

Abstract

Coronavirus disease 2019 (COVID-19) is associated with coagulation abnormalities- disordered hemostasis and high thrombotic risk. The aim of the study was to compare and analyze the clotting profiles between COVID-19 and non-COVID-19 patients in Barau Dikko Teaching Hospital, Kaduna. Conventional coagulation tests such as Activated Partial Thromboplastin Time (APTT), Prothrombin time (PT) and International normalized ratio (INR) were used to determine the coagulation in the respondents. Fifty (50) samples were collected for the test. Out of these samples collected, twenty five 25 were positive for COVID-19. Age group 61-70 had the highest percentage of positive cases 40% while age group 41-50 had the least percentage of positive cases 4% respectively. Concerning gender, males had the higher number of positive cases 15 than their female counterparts 10. All epidemiological and clinical data were collected; analyzed and comparative results were carried out. The presence of history of previous diseases was more among COVID-19 patients than non-COVID-19 patients. The clinical characteristics between COVID-19 and non COVID-19 patients showed similarities in body temperature, catarrh, headache, sore throat and sputum, but the presence of heavy cough was observed among COVID-19 patients. The clinical laboratory results showed significant difference (p<0.05) and positive correlation were found among the PT (0.17), APTT (0.12) and INR (0.08) between COVID-19 and non COVID-19 patients. These results are indications that there is need for more research in this area of study to know the clinical manifestation of COVID-19 virus among patients. Keywords: Coronavirus, Prothrombin, Patients, Thromboplastin