Role of Ascitic Fluid Polymorphic Nuclear Cell Count and Prostaglandin E2 Prognostic Outcome of Cirrhotic Diseased Individual's Mortality

Abstract

Background: One of the most common and dangerous consequences in individuals with decompensated cirrhosis is SBP. Early antibiotic treatment is crucial for effective treatment and lowering death rate. A modulator of the immune response and infection is PGE2. Aim of the Study: To analyze how Prostaglandin E2 and the ascites polymorphic nuclear cell count affect cirrhotic diseased individual mortality prognosis. Material and Methods: Ninety diseased individuals were chosen from the wards of the Internal Medicine Department of Menoufia University Hospitals, the NLI of Menoufia University, and the El Helal Health Insurance Hospital in Shibin Al-Kum for this prospective diagnostic test study. Two cohorts of participants were formed. Cohort I: 45 diseased individuals with hepatic cirrhosis and SBP, as well as 45 diseased individuals without SBP. All diseased individuals had a history review, MELD and CTP scores, a pelvic-abdominal ultrasound, and laboratory investigations such as serum, CBC with differentials made by CRP and ESR, INR and prothrombin time, SAAG, serum creatinine and urea, and liver function tests (ALT and AST), GGT, and Alk.pho. PMN and serum ascitic fluid prostaglandin E2 are included in ascitic fluid analyses. Results: While ascitic fluid PGE2 was elevated in the non-SBP cohort, PMN cell count was elevated in the SBP cohort. Regarding ascitic fluid PGE2, there is a substantial difference between the two cohorts. There are numerous advantages. The relationship between PMN cells and other factors, including ascitic fluid PGE2, Hb, WBC, GGT, alkalinity, and MELD score. The relationship between ascitic fluid PGE2 and other WBC is significantly inverse. Conclusion: both blood and ascitic fluid for the detection and eradication of SBP, as well as for predicting death in cirrhotic diseased individuals, PGDE2 and PMN can be employed as diagnostic and prognostic markers