ChemInform Abstract: Clindanones A and B and Cladosporols F and G, Polyketides from the Deep-Sea Derived Fungus Cladosporium cladosporioides HDN14-342.

ChemInform Pub Date : 2016-12-06 DOI:10.1002/chin.201652419
Zhenzhen Zhang, Xueqian He, Congcong Liu, Qian Che, Tianjiao Zhu, Qianqun Gu, Dehai Li
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Abstract

Cladosporol G (I), together with another three new tetralone derivatives and three known biogenetically related polyketides, is isolated from title deep-sea derived fungus and is shown to have the best cytotoxic activity against HeLa cells with an IC50 value of 3.9 μM.

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摘要:深海衍生真菌Cladosporium cladosporioides HDN14-342的Clindanones A、B和cladsporols F、G多酮类化合物。
Cladosporol G (I)与另外3个新的四肽衍生物和3个已知的生物遗传学相关的聚酮化合物一起从深海真菌中分离得到,对HeLa细胞具有最佳的细胞毒活性,IC50值为3.9 μM。
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