Synthesis, spectroscopic characterization and biological activities of some metal complexes with new heterocyclic azodye ligand 2-(2-hydroxynaphthalen-1-yl azo)-pyridin-3-ol

Q2 Chemistry Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2022.9.006

V. Vidya, V. Sadasivan

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Abstract

Metal complexes of [2-(2-hydroxynaphthalen-1-ylazo)-pyridin-3-ol] are derived from 2-amino-3-hydroxypyridine and β-naphthol was synthesized and characterized by thermal, spectral and analytical tools. The ligand was reacted with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) in 1:2 stoichiometry. The IR spectra confirms the azo ligand coordination to metal ions via azo nitrogen and phenolic oxygen of pyridine after deprotonation. Both IR and 1HNMR spectra recorded involvement of deprotonated hydroxyl groups with proton displacement. The magnified fluorescence was shown by Mn(II) and Ni(II) complexes. None of the prepared ligands or complexes show any NLO activity with KDP as standard. The DNA cleavage and anticancerous activities done. The influence of zinc chelates on cure characteristics of rubber compounds was estimated based on rheometer measurements. The ligand and metal complexes are tested in vitro against some bacteria and fungi species. The antioxidant activities, DNA cleavage and anticancerous activities done. Ligand and its complexes catalysed cleavage of DNA.

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新型杂环偶氮染料配体2-(2-羟基萘-1-酰基偶氮)-吡啶-3-醇金属配合物的合成、光谱表征及生物活性

由2-氨基-3-羟基吡啶和β-萘酚合成了金属配合物[2-(2-(2-萘酞-1-基偶氮)-吡啶-3-醇]，并通过热、光谱和分析手段对其进行了表征。配体与Mn(II)、Fe(II)、Co(II)、Ni(II)、Cu(II)和Zn(II)按1:2的化学计量比例反应。红外光谱证实了偶氮配体在去质子化后通过偶氮氮和吡啶的酚氧与金属离子的配位。红外光谱和1HNMR光谱都记录了质子位移对去质子化羟基的影响。Mn(II)和Ni(II)配合物显示了放大的荧光。制备的配体或配合物均未显示出以KDP为标准的NLO活性。DNA的切割和抗癌活性完成。通过流变仪测量，估计了锌螯合物对橡胶胶料固化特性的影响。配体和金属配合物在体外对一些细菌和真菌进行了测试。具有抗氧化活性、DNA裂解活性和抗癌活性。配体及其复合物催化DNA的裂解。

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

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审稿时长

20 weeks

期刊介绍： The "Current Chemistry Letters" is a peer-reviewed international journal which aims to publish all the current and outstanding research articles, reviews and letters in chemistry including analytical chemistry, green chemistry, inorganic chemistry, organic chemistry, physical chemistry, etc. This journal is dedicated to serve all academic and industrial researchers and scientists who are expert in all major advances in chemistry research. The journal aims to provide the most complete and reliable source of information on current developments in these fields. The emphasis will be on publishing quality articles rapidly and openly available to researchers worldwide. Please note readers are free to read, download, copy, distribute, print, search, or link to the full texts of articles published on this journal. Current Chemistry Letters is an open access journal, which provides instant access to the full text of research papers without any need for a subscription to the journal where the papers are published. Therefore, anyone has the opportunity to copy, use, redistribute, transmit/display the work publicly and to distribute derivative works, in any sort of digital form for any responsible purpose, subject to appropriate attribution of authorship. Authors who publish their articles may also maintain the copyright of their articles.