Oxidised LDL Modulates Endothelin Secretion by Adult Bovine Aortic Endothelial Cells

Endothelium-journal of Endothelial Cell Research Pub Date : 1995-01-01 DOI:10.3109/10623329509024658

H. Sqalli-Houssaini, F. Martin‐Nizard, E. Walters-Laporte, A. Boullier, R. Mackereel, J. Fruchart, P. Duriez

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引用次数: 6

Abstract

An increased level of low density lipoproreins (LDL) in the blood and an accumulation of oxidized-LDL (ox-LDL) in the subendothelium are well known factors of atherosclerosis. Endothelin (ET), a potent vasoconstrictor isolated from endothelial cells, is mitogenic for smooth muscle cells and may participate in atherogenesis by this process. In the present paper we study the effects of native LDL and ox-LDL on ET secretion by adult bovine aortic endothelial cells (ABAE). Native LDL stimulate ET secretion in a dose dependent manner between 25 and 200 μg/ml, while the effects of ox-LDL are complex. A low concentration (50 μg/ml) of highly ox-LDL induces ET secretion while a high concentration (100 μg/ml) does not induce the secretion and is cytotoxic. 100 μ/ml of slightly ox-LDL stimulates the secretion. Our data indicated that the LDL(B/E) receptor pathway is not involved in n-LDL induced ET secretion and are not conclusive on the role of the scavenger receptor pathway in ox-LDL induced ET secretion. Lysolec...

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氧化LDL对成年牛主动脉内皮细胞内皮素分泌的调节作用

低密度脂蛋白(LDL)在血液中的水平升高和氧化LDL (ox-LDL)在内皮下层的积累是众所周知的动脉粥样硬化的因素。内皮素(ET)是一种从内皮细胞中分离出来的强效血管收缩剂，可以促进平滑肌细胞的有丝分裂，并可能通过这一过程参与动脉粥样硬化的形成。本文研究了天然LDL和ox-LDL对成年牛主动脉内皮细胞(ABAE)分泌ET的影响。天然LDL在25 ~ 200 μg/ml之间以剂量依赖性方式刺激ET分泌，而ox-LDL的作用是复杂的。低浓度(50 μg/ml)高ox-LDL诱导ET分泌，高浓度(100 μg/ml)不诱导ET分泌，具有细胞毒性。100 μ/ml轻度ox-LDL刺激分泌。我们的数据表明，低密度脂蛋白(B/E)受体途径不参与n-LDL诱导的ET分泌，并不能确定清除率受体途径在ox-LDL诱导的ET分泌中的作用。Lysolec……

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Endothelium-journal of Endothelial Cell Research

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