The effect of ethinyl-estradiol treatment on the lateral mobility of lipids and proteins in hepatocyte plasma membrane of male rats (FRAP studies on liver smears)
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引用次数: 7
Abstract
The lateral diffusion constants of lipids (D1) and proteins (Dp) in the plasma membranes of hepatocytes were measured in liver smears of male Fischer 344 rats, by means of the fluorescence recovery after photobleaching (FRAP) method, after ethinyl-estradiol (EE) treatment of 1 or 5 days. The main finding was that EE treatment results in significant decreases in both the D1- and the Dp-values. These observations are interpreted in terms of the role of membrane physicochemistry in functions of the hepatocytes.
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