The prognostic role of thrombophilia in the treatment of infertility

Túrós János Levente, Kiss Szilárd-Leó, Bereczky Lujza-Katalin, B. Edina, Lészai Lehel, S. Tamás, Györfi Imola, S. Béla
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Abstract

Abstract Thrombophilia refers to a coagulation disorder that predisposes to thrombosis and thus increases the risk of thrombotic events. Both inherited and acquired thrombophilia are associated with vascular thrombosis and pregnancy-related complications, including infertility, recurrent miscarriage, and premature birth. Recently, thrombophilia has been increasingly encountered as an infertility factor, which gives the clinical relevance of the disease. The aim of the study was to investigate the prognostic role of thrombophilia in the treatment of infertility and the pregnancy of thrombophilic women during assisted reproduction procedures. Frequency of abortions increases and effectiveness of in vitro fertilization (IVF) decreases with age. Normal weight has a positive effect on assisted reproduction techniques (ART’s) outcome. Repeat IVF failure is more common in thrombophilia than in healthy women, and the “take home baby” ratio for IVF is 24%. Spontaneous abortion was most commonly observed in the PAI homozygous group followed by MTHFR homozygous mutation, MTHFR heterozygous mutation, and Factor V (Leiden) mutation. The most effective treatment was concomitant therapy with low molecular weight heparin and aspirin.
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血栓形成在不孕症治疗中的预后作用
血栓病是一种凝血障碍,易形成血栓,从而增加血栓事件的风险。遗传性和获得性血栓形成都与血管血栓形成和妊娠相关并发症有关,包括不孕症、复发性流产和早产。最近,血栓病已经越来越多地遇到作为不孕因素,这给临床相关性的疾病。该研究的目的是调查在辅助生殖过程中治疗不孕症和亲血栓妇女妊娠的预后作用。随着年龄的增长,流产的频率增加,体外受精(IVF)的有效性降低。正常体重对辅助生殖技术(ART)的结果有积极影响。与健康女性相比,血栓患者的重复试管婴儿失败更为常见,试管婴儿“带回家”的比例为24%。自然流产以PAI纯合子组最常见,其次为MTHFR纯合子突变、MTHFR杂合子突变和因子V (Leiden)突变。最有效的治疗是低分子肝素和阿司匹林的联合治疗。
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