Clinical Significance of Clonal Hematopoiesis

Abstract

Clonal hematopoiesis (CH) is associated with somatic mutations of the hematopoietic stem cells responsible for red blood cell formation. The incidence of CH increases with age and negative environmental factors. It is particularly common in patients on chemotherapy, and is associated with a greater than 10-fold increased risk for hematological malignancy. It also increases the risk for cardiovascular disease. Despite recent advances in molecular and genetic research, the clinical and translational aspects of disease require more attention. However, as data accumulate, prevention of disease onset and progression will improve.