Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum

Journal of Nanjing Medical University Pub Date : 2009-05-01 DOI:10.1016/S1007-4376(09)60049-6

Dandan Liu , Zheng Hu , Zhigang Liu , Bo Yang , Wenjuan Tu , Liang Li

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引用次数: 21

Abstract

Objective

To explore a new natural antibiotic.

Methods

The chemical composition of the essential oil from Ganoderma japonicum (G. japonicum) mycelia was analyzed by gas chromatography-mass spectrometry(GC-MS). The antimicrobial activity of the oil was evaluated against eighteen microorganisms, including bacteria, mildew and yeast by using a disc diffusion method. Furthermore, the minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of the essential oil against twelve clinical pathogens were determined.

Results

The main components of the oil were nerolidol, decadienal, linalool and benzyl alcohol. The antimicrobial results indicated that the oil inhibited all the tested bacterium, especially Methicillin-resistant Staphylococcus aureus (MRSA) in which the antibacterial activity exhibited a MBC of 1.03 mg/ml.

Conclusion

The essential oil of G. japonicum mycelium has significant inhibitory activity. It is a potential medicinal resource that can be used as a natural antibiotic.

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日本灵芝菌丝体挥发油化学成分及抑菌活性研究

目的探索一种新的天然抗生素。方法采用气相色谱-质谱联用技术对日本灵芝菌丝体挥发油的化学成分进行分析。采用圆盘扩散法对细菌、霉菌和酵母菌等18种微生物进行了抑菌活性评价。同时测定了精油对12种临床病原菌的最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。结果精油的主要成分为神经樟醇、十烯二醛、芳樟醇和苯甲醇。结果表明，精油对所有细菌均有抑制作用，其中对耐甲氧西林金黄色葡萄球菌(MRSA)的抑菌活性最高，MBC为1.03 mg/ml。结论日本血吸虫菌丝体挥发油具有明显的抑菌活性。它是一种潜在的药用资源，可以用作天然抗生素。

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Journal of Nanjing Medical University

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