Recent contributions of carbonylation reaction to the synthesis of fluorinated pharmaceutical compounds

Abstract

Several organofluorine compounds endowed with unique pharmaceutical activity, such as fluorinated aminoacids, fluorinated arylpropanoic acids, etc. can be conveniently prepared by hydroformylation, hydrocarboxylation and hydroesterification of appropriated olefins containing one or more fluorine atoms in definite positions of the molecule.

Many organic-fluorinated compounds obtained by carbonylation procedures represent very useful intermediates for the synthesis of pharmacologically active molecules, as for instance: fluor-indoles, fluor β-lactams and fluor uracils.