J. Marinel-lo, M. Serra-Prat, C. Albuxeich, P. Carreño, J. Lopez-Palencia, E. Palomera, J. Alós
{"title":"Safety and Efficacy of Amniotic Membrane Implant in Venous Leg Ulcers","authors":"J. Marinel-lo, M. Serra-Prat, C. Albuxeich, P. Carreño, J. Lopez-Palencia, E. Palomera, J. Alós","doi":"10.4172/2329-6925.1000373","DOIUrl":null,"url":null,"abstract":"Objective: To assess the safety and efficacy of amniotic membrane (AM) application in venous leg ulcers (VLU). Methodology: Design: non-controlled pre-post clinical trial. A unique AM fragment was placed on the ulcer in strict sterility conditions. Main outcome measures: total healing rate, percentage of ulcer area reduction and diurnal and nocturnal pain assessment. Control visits: at baseline and 1, 2, 3, 4 and 8 weeks after treatment. Results: Ten patients were recruited (79.6 years). 3 weeks after AM implant, pain had completely disappeared and ulcer area had reduced to nearly halved and, 8 weeks after AM implant, ulcer area was reduced in more than 80% and in two thirds of patients the ulcer was completely healed. No relevant side effects were observed. Conclusions: The present study brings new evidence reinforcing the idea that AM dressing is a safety and effective alternative to heal VLU","PeriodicalId":17397,"journal":{"name":"Journal of Vascular Medicine & Surgery","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Vascular Medicine & Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2329-6925.1000373","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To assess the safety and efficacy of amniotic membrane (AM) application in venous leg ulcers (VLU). Methodology: Design: non-controlled pre-post clinical trial. A unique AM fragment was placed on the ulcer in strict sterility conditions. Main outcome measures: total healing rate, percentage of ulcer area reduction and diurnal and nocturnal pain assessment. Control visits: at baseline and 1, 2, 3, 4 and 8 weeks after treatment. Results: Ten patients were recruited (79.6 years). 3 weeks after AM implant, pain had completely disappeared and ulcer area had reduced to nearly halved and, 8 weeks after AM implant, ulcer area was reduced in more than 80% and in two thirds of patients the ulcer was completely healed. No relevant side effects were observed. Conclusions: The present study brings new evidence reinforcing the idea that AM dressing is a safety and effective alternative to heal VLU