Naphthoquinones: biological properties and synthesis of lawsone and derivates - a structured review

Q3 Pharmacology, Toxicology and Pharmaceutics Vitae Pub Date : 2014-12-03 DOI:10.17533/udea.vitae.17322
Lluvia Itzel LÓPEZ LÓPEZ, Sendar Daniel NERY FLORES, S. Y. SILVA BELMARES, Aidé Sáenz Galindo
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引用次数: 82

Abstract

Background: Naphthoquinones are natural pigments that are widely distributed in nature and have important biological activities. Lawsone (2-hydroxy-1,4-naphthoquinone) and its synthetic derivatives, and especially those containing nitrogen, have promising potential for the treatment of different diseases due to their antibacterial, antifungal, antiviral, antitumor and antiparasitic effects, and for pest control via their molluscicidal and insecticidal activities. Their pharmacological activities and mechanisms of action are related to their oxide/reduction and acid/base properties, and can be modulated by directly adding a substituted to the 1,4-naphthoquinone ring. Due to this, naphthoquinones and their derivatives are at the center of multiple areas of research. In this manuscript, we present a structured review of lawsone, a hydroxyl derivative of naphthoquinone, and discuss relevant reports about the chemistry and synthesis of derivatives. Finally, we present the pharmacological activities and mechanism of action reported. Objective: The purpose of this review is to present recent reports from the literature about the chemistry, synthesis and pharmacological properties of lawsone and its amine derivatives. Methods: This structured review presents a discussion about lawsone literature over the last ten years. The most representative studies including those about the chemistry of lawsone, the synthesis of its derivatives, and pharmacological properties were identified and selected. The information has been compiled, organized and presented into logical topics in order to provide a current review for the field of lawsone chemistry. Results: A general overview of the principal aspects of lawsone chemistry, the synthesis of its derivatives and their pharmacological activities and mechanism of action has been obtained. This provides researchers in the area with a framework from which to investigate further. Conclusions: Lawsone and its derivatives have promising potential for treating several diseases due to their antibacterial, antifungal, antiviral, antitumor and antiparasitic effects and have the potential to control pests via their molluscicidal and insecticidal properties. For this reason, it would be of interest to evaluate the synthetic derivatives of this compound for their pharmacologic actions; in the future, synthetic derivatives of lawsone could potentially be used to treat disease and be used as pesticides.
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萘醌类化合物的生物学性质和合成及其衍生物的结构综述
背景:萘醌是广泛分布于自然界的天然色素,具有重要的生物活性。劳索酮(2-羟基-1,4-萘醌)及其合成衍生物,特别是含氮的衍生物,由于其抗菌、抗真菌、抗病毒、抗肿瘤和抗寄生虫的作用,以及通过其杀螺和杀虫活性来控制害虫,在治疗各种疾病方面具有广阔的潜力。它们的药理活性和作用机制与其氧化还原和酸碱性质有关,可以通过在1,4-萘醌环上直接加入取代基来调节。因此,萘醌及其衍生物是多个研究领域的中心。在这篇文章中,我们对萘醌的羟基衍生物lawsone进行了结构化的综述,并讨论了衍生物的化学和合成的相关报道。最后,我们介绍了所报道的药理活性和作用机制。目的:本文综述了近年来国内外关于lawsone及其胺类衍生物的化学、合成及药理研究的最新报道。方法:本文对过去十年的法律文献进行了结构化的综述。选取了最具代表性的研究成果,包括lawsone的化学性质、衍生物的合成以及药理学性质。这些信息已被汇编、组织和呈现成合乎逻辑的主题,以便为lawsone化学领域提供当前的审查。结果:对lawsone化学的主要方面、衍生物的合成及其药理活性和作用机制进行了综述。这为该领域的研究人员提供了一个进一步研究的框架。结论:Lawsone及其衍生物具有抗菌、抗真菌、抗病毒、抗肿瘤、抗寄生虫等作用,在多种疾病的治疗中具有广阔的应用前景;因此,评价该化合物的合成衍生物的药理作用是有意义的;在未来,lawsone的合成衍生物可能被用于治疗疾病和用作杀虫剂。
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来源期刊
Vitae
Vitae PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: The journal VITAE is the four-monthly official publication of the School of Pharmaceutical and Food Sciences, and its mission is the diffusion of the scientific and investigative knowledge in the various fields of pharmaceutical and food research, and their related industries. The Journal VITAE is an open-access journal that publishes original and unpublished manuscripts, which are selected by the Editorial Board and then peer-reviewed. The editorial pages express the opinion of the Faculty regarding the various topics of interest. The judgments, opinions, and points of view expressed in the published articles are the responsibility of their authors.
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