Study the effect of odanseteron on shivering under spinal anaesthesia for gynaecogical surgeries

Abstract

Aims and Objective: The primary aim was to study the incidence of ondansetron on shivering in patients undergoing elective gynaecological surgeries under spinal anaesthesia and secondary to record vital parameters (HR, SBP, DBP and SpO 2 ) and side effects, if any. Methods: This prospective observational study was performed on 70 ASA grade I and II female patients of 18 to 60 years of age to received either normal saline (Group NS) or Ondansetron (Group ODT ) 0.15mg/kg. Spinal anaesthesia was given to all patients with Bupivacaine 15 mg. 0.5% heavy 3cc + Inj. Norphine 60 microgmat L3 L4 interspace. During surgery, a shivering score was recorded at 5, 10, 15, 20, 25, 30, 60, 120 minutes. Vital parameters in terms of HR, SBP, DBP and SpO 2 and side effects, if any were measured. Results: The incidence of shivering was 8.57% in ondansetron group compared to 40% patients in NS group. Also the incidence of maximum shivering score was high in group NS compared to group ODT. At 25 and 30 minutes, heart rate was significantly greater (82.14 13.06 and 80.6 12.55) in patients receiving normal saline after which it was constant. On the other hand, at 30 and 60 minutes the SBP, DBP and MAP was significantly greater in ondansetron group as compared to normal saline group. Hypotension was comparable in both the groups. Conclusion: The prophylactic administration of ondansetron (0.15mg/kg) I.V. before spinal anaesthesia produces anti-shivering effect, therefore it can be considered as a safe option to prevent post spinal anaesthesia shivering and reduce the risk of hypotension.