Safety and Efficacy of Argatroban in the Management of Heparin-Induced Thrombocytopenia

B. Saugel, R. Schmid, W. Huber
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引用次数: 2

Abstract

Heparin-induced thrombocytopenia (HIT) is a life-threatening adverse reaction to heparin therapy that is characterized by thrombocytopenia and an increased risk of venous and arterial thrombosis. According to guidelines, in patients with strongly suspected or confirmed HIT all sources of heparin have to be discontinued and an alternative, nonheparin anticoagulant for HIT treatment must immediately be started. For both the prophylaxis of thrombembolic events in HIT and the treatment of HIT with thrombosis the direct thrombin inhibitor argatroban is approved in the United States. The objective of this review is to describe the mechanism of action and the pharmacokinetic profile of argatroban, to characterize argatroban regarding its safety and therapeutic efficacy and to discuss its place in therapy in HIT.
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阿加曲班治疗肝素性血小板减少症的安全性和有效性
肝素诱导的血小板减少症(HIT)是肝素治疗的一种危及生命的不良反应,其特征是血小板减少和静脉和动脉血栓形成的风险增加。根据指南,对于强烈怀疑或确诊为HIT的患者,必须停止使用所有来源的肝素,并立即开始使用替代的非肝素抗凝剂治疗HIT。对于HIT患者血栓形成事件的预防和HIT合并血栓形成的治疗,直接凝血酶抑制剂阿加曲班已在美国获得批准。本综述的目的是描述阿加曲班的作用机制和药代动力学特征,描述阿加曲班的安全性和治疗效果,并讨论其在HIT治疗中的地位。
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来源期刊
CiteScore
3.70
自引率
0.00%
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审稿时长
8 weeks
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