Co-occurrence of Wilson disease and Auto-Immune Hepatitis in 14-year-old female: A case report

Fadwa Ghassan Hameed, Inam Sameh Arif, Mohammed Mahmood Mohammed, Hala S. Arif
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引用次数: 1

Abstract

Unusual cases of coexistence between Wilson's disease and autoimmune hepatitis have occurred. There are characteristics of both diseases in this community of patients, and laboratory and histo pathological findings can be misleading. Wilson disease's clinical appearance can differ widely; thus, there is not always an easy diagnosis. In addition to being childhood and young adult illnesses, Wilson's disease can also be triggered at any age. Liver disease and cirrhosis, neuropsychiatric disorders, Kayser-Fleischer(KF.) rings, and acute hemolysis events are the primary characteristics of Wilson's disease, frequently in combination with acute liver failure. Diagnosis is extremely difficult for children and adults with active liver disease. None of the latest Wilson's disease laboratory tests are optimal and may not be specific. Therefore, by taking into account acute hepatitis similar to Wilson's disease and autoimmune hepatitis, concomitant treatment with immunosuppression and penicillamine may have a superior impact.
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14岁女性肝豆状核变性合并自身免疫性肝炎1例
肝豆状核变性与自身免疫性肝炎共存的罕见病例也有发生。这两种疾病在患者群体中都有其特点,实验室和病理组织学结果可能会产生误导。肝豆状核变性的临床表现差异很大;因此,诊断并不总是容易的。除了儿童和年轻人的疾病,威尔逊氏病也可以在任何年龄触发。肝脏疾病和肝硬化、神经精神疾病、Kayser-Fleischer(KF.)环和急性溶血事件是Wilson病的主要特征,经常合并急性肝衰竭。诊断是极其困难的儿童和成人活动性肝病。最新的威尔逊氏病实验室检测没有一项是最佳的,可能也不具体。因此,考虑到类似于Wilson病和自身免疫性肝炎的急性肝炎,免疫抑制和青霉胺联合治疗可能会有更好的效果。
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