Effect Of Roselle Petal Extract On Decreased Levels Of Mda In Rats With Type 2 Diabetes

Abstract

Received: August, 10, 2020 Revised: September, 7, 2020 Available online: February, 2021 Diabetes mellitus type 2 is a metabolic disorder, namely a decrease in peripheral tissues' response to insulin. Free radicals increase, which results in the forming of Malondialdehyde (MDA). Roselle flower petals is an antioxidant to reduce free radical damage. This study aims to analyze the effect of roselle petal extract on decreased MDA levels in mice induced by diabetes. The rats were divided into four treatments group as follow: 1) control negative, 2) control positive, 3) treatment dose I (administering roselle petal extract 195 mg/200 gram body weight), 4) treatment dose II (giving roselle petal extract 260mg/ 200 gram body weight). MDA levels were measured using Thiobarbituric acid (TBA) assay. There was an effect of rosella petal extract in the group with 260 mg/200 of rosella petal extract (p=0.005) and 195 mg/200 of rosella petal extract (p=0.041) compared with the positive control group. Rosella petal extract significantly reduces MDA levels in rats induced by type 2 diabetes.