MANIFESTATIONS OF EPIDEMIC PROCESS OF ROTAVIRUS INFECTION IN NIZHNY NOVGOROD IN PRE-VACCINATION PERIOD

N. Novikova, T. A. Sashina, L. Solntsev, Epifanova Nv, A. Y. Kashnikov, L. V. Pogodina, I. Okun, O. N. Knyagina
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引用次数: 3

Abstract

Aim. Study the manifestations of epidemic process of rotavirus infection in Nizhny Novgorod in pre-vaccination period to evaluate the possible effect on morbidity for the rotavirus vaccine application introduction. Materials and methods. Rotavirus morbidity data were analyzed for the 12-year period (2005 - 2016), as well as its age and season distribution. Rotavirus genotyping was carried out using multiplex PCR and partial sequencing of VP4 and VP7 genes. Results. RVI morbidity in Nizhny Novgorod was shown to be at a moderate level when specific prophylaxis was not applied, multi-year dynamics for morbidity reflects the all-Russian state. 2015 - 2016 were characterized by intensification of the epidemic process in age groups of organized children (3 - 6 and 7 - 14) and adults. Season increase included December-May. seasonal morbidity maximums in different age groups took place during different months. Genetic structure of Nizhny Novgorod population PV-A during this time was presented by 10 types with G9P[8] (44,4%) dominating. Conclusion. Growth of RVI morbidity in Nizhny Novgorod in 2015 - 2016 and changes in age and season manifestations of the infection took place under the condition of change of the dominating genotype PV-A (G4P[8] to G9P[8]).
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下诺夫哥罗德市轮状病毒感染接种前流行过程的表现
的目标。研究下诺夫哥罗德市轮状病毒感染在疫苗接种前的流行过程表现,评价轮状病毒疫苗的应用对发病率的影响。材料和方法。分析了2005 - 2016年12年期间轮状病毒发病率数据及其年龄和季节分布。采用多重PCR和VP4、VP7基因部分测序进行轮状病毒分型。结果。下诺夫哥罗德的RVI发病率在不采用特定预防措施的情况下处于中等水平,发病率的多年动态反映了全俄罗斯的状况。2015 - 2016年的特点是有组织儿童(3 - 6岁和7 - 14岁)和成人年龄组的流行过程加剧。季节增长包括12月至5月。不同年龄组的季节性发病率高峰出现在不同的月份。下诺夫哥罗德群体PV-A在这一时期的遗传结构呈现为10个型,G9P[8](44.4%)占主导地位。结论。2015 - 2016年下诺夫哥罗德地区RVI发病率的增长以及感染年龄和季节表现的变化是在主导基因型PV-A (G4P[8]到G9P[8])发生变化的情况下发生的。
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来源期刊
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
Zhurnal mikrobiologii, epidemiologii, i immunobiologii Immunology and Microbiology-Immunology and Microbiology (miscellaneous)
CiteScore
1.40
自引率
0.00%
发文量
51
审稿时长
8 weeks
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