A Green Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones via One-Pot Multi-Component Reaction by Using Cuttlebone as a Natural Catalyst under Solvent-Free Conditions

Abstract

In this paper, an efficient, green and eco-friendly method for synthesis of 3,4-dihydropyrimidin-2(1 H )-ones via one-pot multi-component reaction of aldehydes, urea and ethyl acetoacetate is shown at the presence of cuttlebone as an effective, reusable and natural heterogeneous catalyst. The advantages of this method are short reaction times, high yields, simple work-up, and reusable natural catalysts. The structure of cuttlebone was characterized by FT-IR spectrum, scanning electron microscopy (SEM) and energy dispersive spectrometer (SEM-EDS).