Effects of Syzygium aromaticum in over weight and obese female patients withPolycystic Ovary Syndrome

Abstract

Background: Polycystic Ovarian Syndrome is that the commonest reproductive endocrine disorder among women of reproductive age, affecting high of population worldwide. It’s the most typical multisystem endocrinopathy having diverse etiopathogenesis in women, causing menstrual irregularities, hirsutism and anovulatory infertility. Objective: To determine the effect of Clove, Syzygium aromaticum supplementation on body weight, BMI, Insulin level, insulin resistanceindexes, fasting glucose level, LH level, Testosterone, androgen binding globulin and lipid profile in over weight and obese women patients with polycystic ovary syndrome (PCOS).Methods: fifteen obese and overweight women with PCOS mean (BMI =32) with mean (age= 29) were enrolled in the study, the clove group (n=50 patients), who were received clove in a dose of 1000 mg daily) for three months. The parameters were measured before and after three months of treatment are: BMI, Fasting plasma glucose, Serum insulin levels, Insulin resistance indexes: (HOMA-B) (HOMA _IR) and (QUICKI). Lipid profile: serum cholesterol, triglycerides, VLDLC, LDL-C and HDL-C, luteinizing hormone LH, testosterone and sex hormone binding globulin.Results: Clove shows no significant decrease in weight,BMI , insulin level andserum cholesterol and QUICKI.with highsignificant decrease in values of glucose, , HOMAB, HOMAIR, ,testosterone ,LH,, triglycerides, VLDL-C and LDL-C and highly significant increase in HDL-C and SHBG concentrations. Conclusion: Clovewashelpful in managementof patients with PCOS throw their ability to decrease the glucose, insulin resistance, lipidprofile, Testosterone and LH and increase the HDL and SHBG.