FDG-PET to monitor early response to infliximab in refractory systemic sarcoidosis

Respiratory Medicine Extra Pub Date : 2007-01-01 DOI:10.1016/j.rmedx.2007.09.004

Alexandra Desvignes , Stéphane Zuily , Leilah Saadi , Pierre Olivier , Denis Regent , Hélène Schuhmacher , Denis Wahl

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引用次数: 1

Abstract

Background

Systemic sarcoidosis can result in dramatic manifestations despite therapeutic escalation. Tumor necrosis factor (TNFα) has a key role in this disease and antagonists of TNFα have been successfully used as an alternative to conventional therapy. We report a case of refractory sarcoidosis with mediastinal, bone and ear, nose, throat (ENT) lesions.

Methods

In this patient we monitored response to treatment by infusions of the anti-TNFα antibody, infliximab, with fluorine 18-fluorodeoxyglucose positron emission tomography (FDG-PET).

Results

Early and spectacular response to infliximab was demonstrated by FDG-PET, which evidenced complete response to treatment.

Conclusion

This case supports use of FDG-PET to evaluate the extent of active disease in refractory sarcoidosis and above all, FDG-PET could be an imaging method of choice showing response to infliximab in refractory sarcoidosis earlier than other imaging techniques.

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FDG-PET监测难治性系统性结节病对英夫利昔单抗的早期反应

背景:系统性结节病可导致戏剧性的表现，尽管治疗升级。肿瘤坏死因子(TNFα)在该疾病中起关键作用，TNFα拮抗剂已成功用于替代常规治疗。我们报告一例难治性结节病与纵隔，骨和耳，鼻，喉(耳鼻喉)病变。方法采用氟18-氟脱氧葡萄糖正电子发射断层扫描(FDG-PET)监测患者输注抗tnf α抗体英夫利昔单抗治疗的反应。结果FDG-PET显示对英夫利昔单抗的早期和显著的反应，证明对治疗完全缓解。结论本病例支持使用FDG-PET评估顽固性结节病活动性疾病的程度，最重要的是，FDG-PET可以作为一种首选的影像学方法，比其他影像学技术更早显示英夫利昔单抗对顽固性结节病的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Respiratory Medicine Extra

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