Study Family History of Psychiatry Disorders in Schizophrenia Patients

A. Mowla, S. Bahrami
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引用次数: 1

Abstract

Background: Schizophrenia is a chronic heterogeneous mental disorder that often has debilitating long-term outcomes. Our aim in this study is to survey history of psychiatric disorders in first-degree relatives of schizophrenia patients and its association with the disease clinical and demographic profile. Methods: In this retrospective study the hospital records of all schizophrenia patients that had been admitted in Ibn Sina Psychiatric Hospital from March 2018 to March 2019 were surveyed. Histories of any psychiatry disorders in the first-degree relatives of the schizophrenia patients were searched. The patients with positive family history were compared with those with negative family history in regard to age of onset, sex, negative symptoms, substance abuse and education level. Results: Of 250 files that were studied, 62 (24.2%) patients had family history of psychiatry disorders. Schizophrenia (10.8%), schizoaffective disorder (7.2%) and bipolar disorder (4.2%) were the most common psychiatry disorders in first-degree relatives of schizophrenia patients. Male sex, lower age at onset, substance abuse, negative symptoms, and lower education were more frequently observed in schizophrenia patients with positive family history. Conclusions: Our study demonstrated that family histories of schizophrenia, schizoaffective and bipolar disorder were higher in family history of schizophrenia patients than normal population. Furthermore, positive family history for psychiatric disorder is associated with worse prognosis in schizophrenia patients. J Neurol Res. 2020;10(6):231-234 doi: https://doi.org/10.14740/jnr631
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精神分裂症患者精神障碍家族史研究
背景:精神分裂症是一种慢性异质性精神障碍,通常具有使人衰弱的长期后果。本研究的目的是调查精神分裂症患者一级亲属的精神病史及其与疾病临床和人口统计学特征的关系。方法:回顾性分析2018年3月至2019年3月在伊本新浪精神病院收治的所有精神分裂症患者的住院记录。检索精神分裂症患者一级亲属的精神疾病病史。比较家族史阳性患者与家族史阴性患者的发病年龄、性别、阴性症状、药物滥用情况和文化程度。结果:在研究的250份档案中,62例(24.2%)患者有精神障碍家族史。精神分裂症(10.8%)、分裂情感性障碍(7.2%)和双相情感障碍(4.2%)是精神分裂症患者一级亲属中最常见的精神障碍。男性、低发病年龄、药物滥用、阴性症状和低文化程度在阳性家族史的精神分裂症患者中更为常见。结论:我们的研究表明,精神分裂症患者的家族史中精神分裂症、分裂情感性和双相情感障碍的家族史高于正常人群。此外,精神分裂症患者的精神障碍家族史阳性与预后较差相关。中华神经科学杂志,2020;10(6):231-234 doi: https://doi.org/10.14740/jnr631
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