Care and Treatment for an Antiphospholipid Syndrome-Related Lower Limb Skin Ulcer Unhealed for 7 Years: A Case Report.

IF 2.9 4区 生物学 Q1 ANATOMY & MORPHOLOGY Cells Tissues Organs Pub Date : 2024-12-01 Epub Date: 2022-03-31 DOI:10.1177/15347346221090079
Min Wei, Yan Xu, Dongyun Xia, Jian Li, Shan Dong
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Abstract

Antiphospholipid syndrome (APS) is a group of rare autoimmune diseases caused by antiphospholipid antibodies that is mainly associated with arterial or venous thrombosis and/or complications during pregnancy. Skin lesions occur in approximately 30% of APS patients as initial manifestations. However, previous studies have primarily focused on the treatment of APS rather than the management of skin lesions. Here, the authors report a case of an APS-related lower limb skin ulcer that had remained unhealed for more than 7 years. The difficulties in this case were the diagnosis of APS, the risk of bleeding during debridement, wound infection, biofilm formation, reduced venous return from the lower limbs, and compliance with compression therapy and follow-up. A three-step wound care regimen based on a multidisciplinary team approach resulted in effective control of APS and healing of the ulcer to the lower leg in 95 days. Over two follow-ups, there was no recurrence of the ulcer.

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抗磷脂综合征相关下肢皮肤溃疡 7 年未愈合的护理和治疗:病例报告。
抗磷脂综合征(APS)是一组由抗磷脂抗体引起的罕见自身免疫性疾病,主要与动脉或静脉血栓和/或妊娠并发症有关。约有 30% 的 APS 患者最初表现为皮肤损害。然而,以往的研究主要集中在 APS 的治疗上,而不是皮损的处理上。在此,作者报告了一例与 APS 相关的下肢皮肤溃疡病例,该溃疡超过 7 年仍未愈合。该病例的难点在于 APS 的诊断、清创过程中的出血风险、伤口感染、生物膜的形成、下肢静脉回流的减少以及对加压疗法和随访的依从性。多学科团队采用三步伤口护理方案,在 95 天内有效控制了 APS,小腿溃疡愈合。在两次随访中,溃疡没有复发。
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来源期刊
Cells Tissues Organs
Cells Tissues Organs 生物-发育生物学
CiteScore
4.90
自引率
3.70%
发文量
45
审稿时长
6-12 weeks
期刊介绍: ''Cells Tissues Organs'' aims at bridging the gap between cell biology and developmental biology and the emerging fields of regenerative medicine (stem cell biology, tissue engineering, artificial organs, in vitro systems and transplantation biology). CTO offers a rapid and fair peer-review and exquisite reproduction quality. Special topic issues, entire issues of the journal devoted to a single research topic within the range of interests of the journal, are published at irregular intervals.
期刊最新文献
Novel Method to Assess Macrophage Phenotype Using Eluted Media. Care and Treatment for an Antiphospholipid Syndrome-Related Lower Limb Skin Ulcer Unhealed for 7 Years: A Case Report. Erratum. Functional Role of the Incisive Duct in Neonatal Dogs. Exploring Mesenchymal Stem Cells versus Minoxidil for Androgenic Alopecia Treatment: A Detailed Animal-Based Histological and Morphometric Study.
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