The potentiation of industrial biocide activity with Cu2+. II. Synergistic effects with 5-chloro-2-methyl-4-isothiazolin-3-one

International Biodeterioration Pub Date : 1990-01-01 DOI:10.1016/0265-3036(90)90023-Z

V.F. Riha , M. Sondossi , H.W. Rossmoore

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引用次数: 10

Abstract

The role of Cu²⁺ in enhancing 5-chloro-2-methyl-4-isothiazolin-3-one (IT) activity was investigated. This study was carried out in two directions. Firstly, the level of enhanced activity from a Cu²⁺ and IT mixture where environmental destruction of IT is minimal was examined. Secondly, the level of protection from Cu²⁺ in environments known to irreversibly reduce IT activity was studied. The bactericidal activities were determined in tryptic soy broth medium, mineral salt base-glucose medium and 0·9 NaCl solution. Under certain conditions, Cu²⁺ also stabilizes and/or protects the sensitive chlorinated IT molecule. Both synergistic activity and stabilization or protection by Cu²⁺ enhance the antimicrobial activity of IT under test conditions. Alternative sequential treatment with IT and Cu²⁺ was used to further characterize enhanced activity. The results suggest synergism. The utility of all the findings was investigated in metalworking fluid.

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Cu2+增强工业杀菌剂活性的研究。2与5-氯-2-甲基-4-异噻唑啉-3- 1的协同效应

研究了Cu2+对5-氯-2-甲基-4-异噻唑啉-3-酮(IT)活性的增强作用。这项研究从两个方向进行。首先，研究了Cu2+和IT混合物的增强活性水平，其中对IT的环境破坏最小。其次，研究了在已知的不可逆地降低IT活动的环境中对Cu2+的保护水平。在色氨酸豆汤培养基、无机盐-葡萄糖培养基和0·9 NaCl溶液中测定了其杀菌活性。在一定条件下，Cu2+还可以稳定和/或保护敏感的氯化IT分子。在实验条件下，协同活性和Cu2+的稳定或保护作用都增强了IT的抗菌活性。使用IT和Cu2+交替顺序治疗进一步表征增强的活性。结果显示协同作用。研究了这些结果在金属加工液中的应用。

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