Association of Latin-American Ethnicity with an Increase in Weight in an HIV-Infected Outpatient Population

Abstract

Objective: To explore weight gain in regular practice involving naïve patients, those who continue the same treatment for at least 6 months or those who changed their antiretroviral treatment. Methods: We performed a retrospective analysis of patients followed-up between 2013 and 2019. This study included 3 groups of participants (naïve patients, those who had been on viral suppression for more than 6 months, and those with a treatment change). Results: 317 people living with HIV (PLHIV) participated. The proportion of participants in the overweight and obese categories increased over time, from 40 to 43% and from 9.46% to 12.43% respectively. Proportion of metabolic syndrome increased overtime from 3.79 to 6.22%. Stratification by both sex and ethnicity, showed the greatest weight gain among Latin male. Considering the risk factors for HIV infection, men that had sex with men (MSM) and heterosexual patients gained 2.03 (95% CI, 0.42-3.65; p =0.013) and 1.57 (95% CI 0.12-3.02; p =0.034) kg more than those who were former intravenous kg Elvitegravir suggest that there are demographic, HIV and treatment related contributors to weight gain in PLHIV. Latin-American ethnic associated gain, in male sex. We could not find any association of weight gain with sex, age or group of treatment six months or change of We found boosted PI-based regimens, LPV/r, EVG/c and RPV, and TAF among nucleoside reverse transcriptase inhibitors (NRTI) associated with the gain. clinical maintenance healthy weight implement for patients starting treatment but also for those with a long experience in antiretroviral treatment.