Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion

eduarda Santa-Helena, Camila Wally, Joaquim de Paula Ribeiro, A. P. Votto, Carla Amorim Neves Gonçalves
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Abstract

Objective : In this work, rats isolated hearts were infused EPA before the ischemia period and during reperfusion for available get well in parameter relatives to redox reactions.  Methods : The effect of EPA was tested on isolated hearts induced to ischemia and reperfusion, treatment occurred at different times (ischemia or reperfusion). Antioxidant capacity against peroxyl radicals, glutathione cysteine ligase activity, glutathione concentration, lactate dehydrogenase, and creatine kinase concentration was analyzed. Results : Hearts treated with eicosapentaenoic acid had the minor generation of species reactive oxygen and lipid damage after reperfusion. The GSH concentration was higher when the hearts were treated with eicosapentaenoic acid in the period of reperfusion. Conclusion : In conclusion, this study demonstrates that the dose of EPA (20μM) used before ischemia can act as a cardioprotective antioxidant molecule, prevented damage heart from ischemic and reperfusion injury.
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二十碳五烯酸对心肌缺血再灌注的保护作用
目的:在大鼠离体心脏缺血前和再灌注时灌注EPA,以获得良好的氧化还原反应相关参数。方法:观察EPA对离体心脏缺血再灌注的影响,分别在不同时间(缺血或再灌注)给药。分析了抗过氧自由基能力、谷胱甘肽半胱氨酸连接酶活性、谷胱甘肽浓度、乳酸脱氢酶和肌酸激酶浓度。结果:经二十碳五烯酸处理的心脏在再灌注后产生少量的活性氧和脂质损伤。再灌注时用二十碳五烯酸处理的心脏GSH浓度较高。结论:本研究表明,缺血前给药剂量EPA (20μM)可起到保护心脏的抗氧化分子作用,防止心肌缺血和再灌注损伤。
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