Hyperthermia for Oral Cancer

Abstract

: Dysfunctions and cosmetic disturbance after surgery for oral cancer are major problem. I focused hyperthermia as non-invasive therapy for oral cancer. Magnetic induction interstitial hyperthermia using ferromagnetic implant needle (Implant heating system : IHS) has been developed, and the antitumor effectiveness was studied experimentally and clinically for tongue cancer. The effectiveness of hyperthermia tended to extend gradually toward the peripheral side of the tongue tumor inoculated VX7. Eight patients with primary cancer of the oral cavity were treated using hyperthermia combined with chemotherapy. As a result, the thermal distribution was good, and complete response was observed in all patients. The antitumor effectiveness of interstitial hyperthermia using magnetic liposomes was studied experimentally. The primary tongue tumor was disappeared due to good thermal distribution. Magnetic liposomes were delivered selectively to the cervical lymph node metastasis. Then, necrosis and apoptosis were observed in the cervical lymph node metastasis under alternating magnetic field. Ferucarbotran of existing drugs was heated under alternating magnetic field. Combination of cisplatin with ferucarbotran under alternating magnetic field induced apoptosis of cancer cells more effectively than cisplatin alone with significant differences. A new anti-cancer agent for magnet-guided delivery with anti-cancer activity (Fe (Salen)) was studied experimentally in terms of antitumor effectiveness. Fe (Salen) alone inhibited the growth of tongue tumor. The heat was confirmed in Fe (Salen) under alternating magnetic field, and tongue tumor was disappeared with interstitial hyperthermia using Fe (Salen). The combined therapy with superselective intra-arterial chemoradiotherapy and RF hyperthermia was effective therapy for advanced oral cancer with cervical lymph node metastasis (N3). This therapy is promising as a new strategy of non-invasive therapy for advanced oral cancer.