Is There Evidence that Linalool Causes Allergic Contact Dermatitis?

J. Hostynek,, H. Maibach
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引用次数: 1

Abstract

The fragrance material linalool has been cited as a moderately frequent cause of allergic contact dermatitis. The literature shows that when the underlying clinical and experimental data are analyzed, a clear cause-effect relationship has infrequently or rarely been established. On the basis of the generally weak sensitizing potential of this substance coupled with its generally low exposure conditions, the prevalence of clinical cases would not be expected to be particularly high. This is not to say that linalool is a frequent inducer of type IV allergy in members of the public. However, it remains to be seen how often such an allergy, once established, is responsible for any of the cases of allergic contact dermatitis commonly ascribed in the literature. Indeed, in some cases, patch test conditions may not be optimal for differentiating between clinically relevant and irrelevant allergy to linalool.
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有证据表明芳樟醇会引起过敏性接触性皮炎吗?
芳香物质芳樟醇被认为是引起过敏性接触性皮炎的常见原因。文献表明,在分析基础临床和实验数据时,很少或很少建立明确的因果关系。鉴于该物质的致敏潜力普遍较弱,再加上其暴露条件普遍较低,预计临床病例的发生率不会特别高。这并不是说芳樟醇是公众中IV型过敏的常见诱因。然而,这还有待观察,多久这种过敏,一旦建立,负责过敏性接触皮炎的任何情况下,通常归于文献。事实上,在某些情况下,斑贴试验条件可能不是区分临床相关和不相关的芳樟醇过敏的最佳方法。
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Acknowledgement to Referees for Exogenous Dermatology 2004 Contents Vol. 3, 2004 Author Index Vol. 3, 2004 Is There Evidence that Geraniol Causes Allergic Contact Dermatitis? Subject Index Vol. 3, 2004
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