The role of microRNA-613 and its related genes in ovarian cancer

The Ukrainian Biochemical Journal Pub Date : 2023-02-23 DOI:10.15407/ubj94.06.011

M. M. Mohammed, M. Ramzy, S. Gaber, H. Mohamed, M. Mohamed, A. M. Abdalla

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Abstract

Ovarian cancer (OC) is the most lethal gynecological cancer. Multiple genetic and epigenetic abnormalities have been detected in ovarian cancers. As microRNAs (miRNAs) play important roles in carcinogenesis, numerous researchers aim to determine the molecular mechanism that regulates the cancer cells proliferation and metastasis. In the current study, the expression of microRNA-613 and related KRAS and Ezrin genes was assessed by Real-time PCR in ovarian cancer tissue and the adjacent apparently normal tissues. Our results revealed that the expression of miRNA-613 was downregulated in ovarian cancer while the expression of KRAS and Ezrin was higher in cancer tissues compared to apparently normal ovarian tissues. There was a negative correlation between the expression of miRNA-613 and both KRAS and Ezrin genes expression and a positive correlation between KRAS and Ezrin gene expression. The results obtained confirm that miRNA-613 acts as a tumor-suppressive gene in ovarian cancer and can realize such impact through the expression of KRAS and Ezrin genes. These data contribute to the identification of potential biomarkers and novel targets for OC early detection and treatment. Keywords: Ezrin, gene expression, KRAS, miRNA-613, ovarian cancer

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microRNA-613及其相关基因在卵巢癌中的作用

卵巢癌(OC)是最致命的妇科癌症。在卵巢癌中发现了多种遗传和表观遗传异常。由于microRNAs (miRNAs)在癌变过程中发挥着重要作用，许多研究者致力于确定其调控癌细胞增殖和转移的分子机制。本研究采用Real-time PCR技术检测了microRNA-613及相关KRAS、Ezrin基因在卵巢癌组织及癌旁表面正常组织中的表达情况。我们的研究结果显示，miRNA-613在卵巢癌中表达下调，而KRAS和Ezrin在卵巢癌组织中的表达高于表面正常的卵巢组织。miRNA-613的表达与KRAS和Ezrin基因的表达均呈负相关，与KRAS和Ezrin基因的表达呈正相关。结果证实miRNA-613在卵巢癌中作为肿瘤抑制基因，并通过KRAS和Ezrin基因的表达实现抑癌作用。这些数据有助于识别潜在的生物标志物和卵巢癌早期检测和治疗的新靶点。关键词:Ezrin，基因表达，KRAS, miRNA-613，卵巢癌

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The Ukrainian Biochemical Journal

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