Comparison of Biochemical Test Results with a Portable Point-of-Care Analyzer and a Reference Laboratory Analyzer in Eastern Indigo Snakes (Drymarchon couperi)

Falicia Dickerson, J. Bogan, Michelle Hoffman, C. Cray, Frederick B. Antonio
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Abstract

Abstract Eastern indigo snakes (EIS; Drymarchon couperi) have unique physiological features that are not well understood. A useful tool to better understand the physiology of this species is reference intervals for plasma biochemical analytes; however, reported values for such analytes are often specific to the analyzer used. To determine whether a point-of-care analyzer would produce results comparable with those of a veterinary reference laboratory analyzer, this study aimed to compare plasma biochemical analyte values between these two types of analyzers, regardless of EIS health status. Plasma biochemical analyte values were obtained from 31 EIS and were compared between analyzers. The analytes were albumin (ALB), aspartate aminotransferase (AST), total calcium (Ca), creatinine kinase (CK), glucose (GLU), potassium (K), sodium (Na), phosphorus (P), total protein (TP), and uric acid (UA). A very high correlation between analyzers was found for AST (r = 0.923), K (r = 0.916), and UA (r = 0.965); a high correlation for Ca (r = 0.724), CK (r = 0.789), GLU (r = 0.889), and TP (r = 0.812); and a moderate correlation for P (r = 0.528), a low correlation for ALB (r = 0.471), and no correlation for Na (r = -0.138). A point-of-care analyzer offers many benefits such as portability, rapid results, small sample-size requirements, and the ability to use whole blood. The Vetscan VS2 point-of-care analyzer produces similar values for only some analytes, signifying the need for method-specific reference intervals for plasma biochemical analytes in EIS.
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便携式定点分析仪与实验室参比分析仪对东部靛蓝蛇生化检测结果的比较
东方靛蓝蛇(EIS;赤杨(Drymarchon couperi)具有独特的生理特征,但尚未得到很好的理解。血浆生化分析的参考区间是更好地了解该物种生理的有用工具;然而,这些分析物的报告值通常是特定于所使用的分析器的。为了确定护理点分析仪是否能产生与兽医参考实验室分析仪相当的结果,本研究旨在比较这两种分析仪之间的血浆生化分析值,而不考虑EIS的健康状况。从31个EIS中获得血浆生化分析值,并在分析仪之间进行比较。分析物为白蛋白(ALB)、天冬氨酸转氨酶(AST)、总钙(Ca)、肌酐激酶(CK)、葡萄糖(GLU)、钾(K)、钠(Na)、磷(P)、总蛋白(TP)和尿酸(UA)。AST (r = 0.923)、K (r = 0.916)和UA (r = 0.965)的相关性非常高;Ca (r = 0.724)、CK (r = 0.789)、GLU (r = 0.889)、TP (r = 0.812)呈高度相关;P有中等相关性(r = 0.528), ALB有低相关性(r = 0.471), Na无相关性(r = -0.138)。即时分析仪具有许多优点,如便携性、快速结果、小样本量要求以及使用全血的能力。Vetscan VS2即时分析仪仅对某些分析物产生类似的值,这表明EIS中血浆生化分析物需要特定方法的参考区间。
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