Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study

IF 0.8 Q3 MULTIDISCIPLINARY SCIENCES Makara Journal of Science Pub Date : 2021-12-30 DOI:10.7454/mss.v25i4.1248
Gabriella Chandrakirana Krisnamurti, Dewi Ratih Tirto Sari, Y. Bare
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引用次数: 9

Abstract

The number of tuberculosis (TB) cases worldwide reached 1.5 million in 2018; thus, TB is considered a deadly disease. TB is caused by Mycobacterium tuberculosis and involves lipid synthesis. Considering the importance of lipid metabolism in bacteria, FabH may be an essential protein target for repressing lipid synthesis. Capsaicinoids from Capsicum annuum demonstrate potent antibacterial activity. This study predicted the ability of capsaicinoid compounds to inhibit FabH. In silico analysis was performed by retrieving the structure of FabH from PDB and those of selected capsaicinoid derivatives from PubChem. The compounds were docked using AutoDock Vina in PyRx 0.8 software. The interactions of FabH and different capsaicinoid derivatives showed identical binding characteristics. The bonding type most frequently observed was hydrogen bonds. In conclusion, capsaicinoid derivatives could block lipid synthesis through FabH. The relevant mechanism and biological processes should be studied further.
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辣椒素作为结核分枝杆菌FabH抑制剂的硅片研究
2018年,全球结核病病例数达到150万;因此,结核病被认为是一种致命的疾病。结核病由结核分枝杆菌引起,涉及脂质合成。考虑到细菌脂质代谢的重要性,FabH可能是抑制脂质合成的重要蛋白靶点。辣椒中的辣椒素具有较强的抗菌活性。本研究预测了辣椒素类化合物抑制FabH的能力。通过从PDB中检索FabH的结构和从PubChem中选择的辣椒素衍生物的结构进行硅分析。使用PyRx 0.8软件中的AutoDock Vina进行化合物对接。FabH与不同辣椒素衍生物的相互作用表现出相同的结合特性。最常观察到的成键类型是氢键。综上所述,辣椒素衍生物可通过FabH阻断脂质合成。相关机制和生物学过程有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Makara Journal of Science
Makara Journal of Science MULTIDISCIPLINARY SCIENCES-
CiteScore
1.30
自引率
20.00%
发文量
24
审稿时长
24 weeks
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