FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT: A REVIEW

Abstract

Floating drug delivery system was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single unit and multiple unit floating systems. In the recent decades, there have been numerous attempts to overcome the barrier like short gastric residence times and unpredictable gastric emptying times. This review also summarizes the in –vitro technique of evaluation, all the pre-formulation and post formulation evaluations criteria. These systems are useful to several problems encountered during the development of pharmaceutical dosage form. In this review, the technologies of formulation and mechanism of drug release, advantage, application in drug delivery of floating systems are discussed.