Seroprevalence of Diphtheria IgG Antibody in Relation with Socio-demographic Change at a Tertiary Care Hospital in Bangladesh

Journal of National Institute of Neurosciences Bangladesh Pub Date : 2022-02-06 DOI:10.3329/jninb.v7i2.58112

Khandaker Md Tasnim Sajid, P. Das, Tarana Jahan, Shib Prasad Sinha, Toufique Tania Prity, Md Arifur Rahman, Siddika Khatun

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Abstract

Background: Seroprevalance of diphtheria antibody may vary in different socioeconomic people. Objective: The purpose of the present study was to determine the seroprevalence of diphtheria IgG antibody and to identify the relationship between diphtheria seroprevalence and several sociodemographic characteristics. Methodology: This cross-sectional study was conducted in the Department of Microbiology at Sylhet MAG Osmani Medical College, Sylhet, Bangladesh from July 2016 to June 2017 for duration of one year. Apparently healthy individuals were enrolled in this study as study population by following a set of inclusion and exclusion criteria. For laboratory procedure, anti-diphtheria antibody titer was measured by ELISA method. Result: A total number of 200 healthy individuals were recruited for this study. The mean serum IgG level was 0.23±0.26 IU/mL in participants of aged between 18 to 25 years which was much lesser in participants of aged between 26 to 32 years and 33 to 38 years group (p=0.001). Mean serum IgG level was 0.12±0.12 IU/mL in male participants. Majority participants have been come from lower middle class having mean serum IgG level of 0.10±0.21 IU/mL. Conclusion: In conclusion diphtheria IgG level is most commonly found among young male adult person in upper middle class socioecomonic condition. Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 156-160

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孟加拉国三级保健医院白喉IgG抗体血清流行率与社会人口变化的关系

背景:白喉抗体的血清阳性率在不同社会经济人群中可能存在差异。目的:本研究的目的是测定白喉IgG抗体的血清阳性率，并确定白喉血清阳性率与一些社会人口学特征的关系。方法:本横断面研究于2016年7月至2017年6月在孟加拉国Sylhet MAG Osmani医学院微生物学系进行，为期一年。按照一套纳入和排除标准，将明显健康的个体作为研究人群纳入本研究。实验室程序用ELISA法测定抗白喉抗体滴度。结果:本研究共招募了200名健康个体。18 ~ 25岁组血清IgG水平为0.23±0.26 IU/mL，而26 ~ 32岁组和33 ~ 38岁组血清IgG水平明显低于25 ~ 25岁组(p=0.001)。男性平均血清IgG水平为0.12±0.12 IU/mL。大多数参与者来自中下阶层，平均血清IgG水平为0.10±0.21 IU/mL。结论:白喉IgG水平以中上层社会经济条件下的年轻成年男性最为常见。《孟加拉国国家神经科学研究所杂志》，2021年7月，第7卷，第2期，156-160页

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Journal of National Institute of Neurosciences Bangladesh

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