Current insights into the role of Fli-1 in hematopoiesis and malignant transformation.

IF 1.9 4区管理学 Q2 COMMUNICATION Management Communication Quarterly Pub Date : 2022-02-28 DOI:10.1007/s00018-022-04160-1

Yaacov Ben-David, Babu Gajendran, Klarke M Sample, Eldad Zacksenhaus

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Abstract

Fli-1, a member of the ETS family of transcription factors, was discovered in 1991 through retroviral insertional mutagenesis as a driver of mouse erythroleukemias. In the past 30 years, nearly 2000 papers have defined its biology and impact on normal development and cancer. In the hematopoietic system, Fli-1 controls self-renewal of stem cells and their differentiation into diverse mature blood cells. Fli-1 also controls endothelial survival and vasculogenesis, and high and low levels of Fli-1 are implicated in the auto-immune diseases systemic lupus erythematosus and systemic sclerosis, respectively. In addition, aberrant Fli-1 expression is observed in, and is essential for, the growth of multiple hematological malignancies and solid cancers. Here, we review the historical context and latest research on Fli-1, focusing on its role in hematopoiesis, immune response, and malignant transformation. The importance of identifying Fli-1 modulators (both agonists and antagonists) and their potential clinical applications is discussed.

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目前对 Fli-1 在造血和恶性转化中作用的认识。

Fli-1 是 ETS 转录因子家族的成员，1991 年通过逆转录病毒插入诱变发现，是小鼠红白血病的驱动因子。在过去的 30 年中，近 2000 篇论文对其生物学特性以及对正常发育和癌症的影响进行了定义。在造血系统中，Fli-1 控制着干细胞的自我更新和分化成各种成熟血细胞。Fli-1 还控制着内皮细胞的存活和血管生成，高水平和低水平的 Fli-1 分别与自身免疫性疾病系统性红斑狼疮和系统性硬化症有关。此外，在多种血液恶性肿瘤和实体瘤中也可观察到 Fli-1 的异常表达，而且这种表达对它们的生长至关重要。在此，我们回顾了有关 Fli-1 的历史背景和最新研究，重点关注其在造血、免疫反应和恶性转化中的作用。讨论了确定 Fli-1 调节剂（激动剂和拮抗剂）及其潜在临床应用的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Management Communication Quarterly Multiple-

CiteScore

4.30

自引率

16.00%

发文量

期刊介绍： Management Communication Quarterly presents conceptually rigorous, empirically-driven, and practice-relevant research from across the organizational and management communication fields and has strong appeal across all disciplines concerned with organizational studies and the management sciences. Authors are encouraged to submit original theoretical and empirical manuscripts from a wide variety of methodological perspectives covering such areas as management, communication, organizational studies, organizational behavior and HRM, organizational theory and strategy, critical management studies, leadership, information systems, knowledge and innovation, globalization and international management, corporate communication, and cultural and intercultural studies.