Apresoline Promoted Acrolein Reduction in Patient with Relapsing Remitting Multiple Sclerosis

Abstract

Background: Acrolein has been implicated as an irritating/exacerbating factor in animal models of relapsing-remitting multiple sclerosis. In animal studies, Apresoline (Hydralazine) has acted as a successful acrolein scavenging agent and resulted in reduced behavioral deficits and decreased myelin damage. It has been hypothesized that Apresoline would be equally successful as a disease modifying treatment for relapsing-remitting multiple sclerosis. Objective: To describe the case of acrolein reduction in a patient with relapsing-remitting multiple sclerosis taking Apresoline. Methods: Case study. Results: The patient was diagnosed with relapsing-remitting multiple sclerosis and found to have an elevated level of acrolein. After 60 days of Apresoline treatment, the patient’s acrolein level was reduced to a normal level. Dosage was reduced to establish a minimum effective dosage with no assessed increase in relapsing-remitting multiple sclerosis activity. Conclusion: Elevated levels of acrolein were documented in this relapsing-remitting multiple sclerosis patient. Apresoline was demonstrated to be an effective acrolein scavenger in this patient and a minimum effective dosage was established.