Reference values and biological determinants for cardiac myosin-binding protein C concentrations assessed with an enzyme-linked immunosorbent assay.

IF 1.6 3区农林科学 Q2 AGRONOMY Genetic Resources and Crop Evolution Pub Date : 2023-10-27 DOI:10.5937/jomb0-39081

Sylwester M Kloska, Marek Kozinski, Anna Stefanska, Katarzyna Bergmann, Aneta Mankowska-Cyl, Joanna Siodmiak, Grazyna Sypniewska, Magdalena Krintus

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Abstract

Background: Cardiac myosin-binding protein C (cMyC) is a novel cardio-specific biomarker of potential diagnostic and prognostic value for cardiovascular events. This study aims to determine reference values for cMyC and identify biological determinants of its concentration.

Methods: A population of 488 presumably healthy adults were enrolled to define biological determinants which affect cMyC concentrations in serum. Concentrations of cMyC were assessed using enzyme-linked immunosorbent assays from commercially available kits. Eligibility for inclusion in this study evaluated all subjects' anthropometric, demographic and laboratory measurements. After applying strict inclusion criteria, a reference population (n=150) was defined and used to determine reference values. Reference values were derived using a robust method.

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用酶联免疫吸附试验评估心脏肌球蛋白结合蛋白 C 浓度的参考值和生物学决定因素。

背景：心脏肌球蛋白结合蛋白 C（cMyC）是一种新型心血管特异性生物标志物，对心血管事件具有潜在的诊断和预后价值。本研究旨在确定 cMyC 的参考值，并确定其浓度的生物学决定因素：方法：研究人员招募了 488 名假定健康的成年人，以确定影响血清中 cMyC 浓度的生物决定因素。使用市售试剂盒中的酶联免疫吸附测定法评估 cMyC 的浓度。本研究对所有受试者的人体测量、人口统计学和实验室测量结果进行了评估。在采用严格的纳入标准后，确定了参考人群（n=150）并用于确定参考值。参考值采用稳健的方法得出。

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来源期刊

Genetic Resources and Crop Evolution 农林科学-农艺学

CiteScore

4.10

自引率

10.00%

发文量

178

审稿时长

3 months

期刊介绍： Genetic Resources and Crop Evolution is devoted to all aspects of plant genetic resources research. It publishes original articles in the fields of taxonomical, morphological, physiological, biochemical, genetical, cytological or ethnobotanical research of genetic resources and includes contributions to gene-bank management in a broad sense, that means to collecting, maintenance, evaluation, storage and documentation. Areas of particular interest include: -crop evolution -domestication -crop-weed relationships -related wild species -history of cultivated plants including palaeoethnobotany. Genetic Resources and Crop Evolution also publishes short communications, e.g. newly described crop taxa, nomenclatural notes, reports of collecting missions, evaluation results of gene-bank material etc. as well as book reviews of important publications in the field of genetic resources. Every volume will contain some review articles on actual problems. The journal is the internationalized continuation of the German periodical Die Kulturpflanze, published formerly by the Institute of Plant Genetics and Crop Plant Research at Gatersleben, Germany. All contributions are in the English language and are subject to peer reviewing.