An Yunhe, Zhang Haofeng, S. Min, Z. Jun, Chen Xiuqin, Chen Dong, L. Di, F. Jing, Yang Dongling, S. Lina, Y. Xiyun, 阎锡蕴, J. Zhang
{"title":"sTn is a Novel Biomarker for Type I Endometrial Carcinoma","authors":"An Yunhe, Zhang Haofeng, S. Min, Z. Jun, Chen Xiuqin, Chen Dong, L. Di, F. Jing, Yang Dongling, S. Lina, Y. Xiyun, 阎锡蕴, J. Zhang","doi":"10.3724/SP.J.1206.2012.00185","DOIUrl":null,"url":null,"abstract":"Sialyl-Tn(sTn) is a tumor-associated carbohydrate antigen overexpressed in many carcinomas.But whether it is expressed in neoplastic human endometrium is controversial.Here we screened 111 clinical samples including 82 endometrial cancers,16 atypical hyperplastic and 13 normal endometria,by immunohistochemistry using a novel anti-sTn antibody,namely 3P9.Our results showed that the expression of sTn in the endometrial carcinoma was significantly higher(76%) than that in normal tissues(31%)(P 0.01) and in atypical hyperplasia(44%)(P 0.05).Importantly,we found that sTn expression in typeⅠ carcinoma(80%) was obviously higher than that in typeⅡ(45%)(P 0.05).These results suggested that sTn may be a biomarker for endometrial carcinoma,especially for typeⅠcarcinoma.Moreover,we observed that sTn expression was increased with the decline of tumor histological grade(P 0.05),indicating that sTn was associated with a favorable prognosis in endometrial carcinoma.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"40 1","pages":"548-555"},"PeriodicalIF":0.2000,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"生物化学与生物物理进展","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3724/SP.J.1206.2012.00185","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 2
Abstract
Sialyl-Tn(sTn) is a tumor-associated carbohydrate antigen overexpressed in many carcinomas.But whether it is expressed in neoplastic human endometrium is controversial.Here we screened 111 clinical samples including 82 endometrial cancers,16 atypical hyperplastic and 13 normal endometria,by immunohistochemistry using a novel anti-sTn antibody,namely 3P9.Our results showed that the expression of sTn in the endometrial carcinoma was significantly higher(76%) than that in normal tissues(31%)(P 0.01) and in atypical hyperplasia(44%)(P 0.05).Importantly,we found that sTn expression in typeⅠ carcinoma(80%) was obviously higher than that in typeⅡ(45%)(P 0.05).These results suggested that sTn may be a biomarker for endometrial carcinoma,especially for typeⅠcarcinoma.Moreover,we observed that sTn expression was increased with the decline of tumor histological grade(P 0.05),indicating that sTn was associated with a favorable prognosis in endometrial carcinoma.
期刊介绍：
Progress in Biochemistry and Biophysics is a monthly, peer-reviewed journal sponsored by Institute of Biophysics, The Chinese Academy of Sciences together with Biophysical Society of China. It started publication in 1974. It mainly reports on the latest developments in biochemistry, biophysics, molecular biology and neuroscience both in China and abroad. It contains several columns such as "reviews and monographs", "rapid and short communications", "research papers", "techniques and methods" and "academic discussions".
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